高雄榮民總醫院婦女醫學部主任 / 生殖醫學中心主持人 醫學博士 / 商業經營管理碩士

+886-921858600   khtsui60@gmail.com 

學歷 

中山大學生物科學系博士 

中山大學高階經營管理碩士 

荣民总医院醫學院醫學系學士 

經歷 

台灣生殖醫學會理事 

台灣子宮內膜異位症學會理事 

內視鏡暨微創醫學會理事 

台湾健康署諮詢委員 

人工生殖機構評鑑委員 

人工生殖機構施術醫師資格評審委員 婦產專科醫師評鑑審查委員 

台灣婦產科醫學會監事 

荣民总医院醫學院臨床教授 

中山大學生物醫學研究所合聘副教授

專長 

1. 不孕症治療：人工授精、試管嬰兒、精卵顯微注射、雷射助孵化、胚胎植入、精卵捐贈、冷凍儲存（胚胎、精液、卵子）、胚胎著床前基因篩檢 PGT-A (PGS)、胚胎著床前基因診斷 PGT-M (PGD)。

2. 子宮內膜異位症、子宮肌瘤。

3. 內分泌治療：多囊性卵巢症候群。

4. 腹腔鏡手術、子宮鏡、海芙刀等生殖外科手術。

科室經營與績效 

高雄榮民總醫院生殖實驗室創始人，全程負責實驗室的規劃與設計，積極培育人才。領導高雄榮民總醫院生殖醫學中心取得人工生殖機構施術醫師訓練資格，亦成為台灣南部地區業務量成長最快之生殖實驗室，維持高水準之醫療服務品質及成功率，不分年齡平均懷孕率近 50%，小於 38 歲平均懷孕率約 60%。 

迄今發表 SCI 文章共 115 篇，近五年發表 SCI 文章共 59 篇。 

論文列表（近三年）：

1. Su WP, Li CJ, Lin LT, Lin PH, Wen ZH, Sheu JJ, Tsui KH. Boosting mitochondrial function and metabolism in aging female germ cells with dual ROCK/ROS inhibition. Biomed Pharmacother. 2023 Jul;163:114888.

2. Lin PH, Su WP, Li CJ, Lin LT, Sheu JC, Wen ZH, Cheng JT, Tusi KH. Multi-omics analysis for evaluating ferroptosis-related genes in ovarian aging and their improvement through nutritional intervention. Nutrients. 2023 15:2461.

3. Chang WS, Lin PH, Li CJ, Chern CU, Chen YC, Lin LT, Tsui KH. Additional single dose GnRH agonist during luteal phase support may improve live birth rate in GnRHa-HRT frozen-thawed embryo transfer cycle: a retrospective cohort study. BMC Pregnancy Childbirth. 2023 Mar 14;23(1):174.

4. Tsai HW, Tsui KH, Chiu YC, Wang LC. Adverse effect of lactobacilli-depauperate cervicovaginal microbiota on pregnancy outcomes in women undergoing frozen-thawed embryo transfer. Reprod Med Biol. 2023 Jan 20;22(1):e12495.

5. Tsui KH, Li CJ. Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes. Aging (Albany NY). 2023 Jan 9;15(1):246-260.

6. Pan LF, Chang R, Hsu CY, Tsui KH. Older veterans associated with reduced risk of cancer: Retrospective nationwide matched cohort study in Taiwan. Front Med (Lausanne). 2023 Jan 4;9:931565.

7. Tsai TE, Lin PH, Lian PF, Li CJ, Vitale SG, Mikuš M, Su WP, Tsai HW, Tsui KH, Lin LT. Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles. J Ovarian Res. 2022 Sep 9;15(1):102.

8. Tzeng YT, Tsui KH, Tseng LM, Hou MF, Chu PY, Sheu JJ, Li CJ. Integrated analysis of pivotal biomarker of LSM1, immune cell infiltration and therapeutic drugs in breast cancer. J Cell Mol Med. 2022 Jul;26(14):4007-4020.

9. Tsai HW, Li CJ, Lin LT, Chiang AJ, Chen SN, Wen ZH, Tsui KH. Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancer. Aging (Albany NY). 2022 May 4;14(9):3874-3886.

10. Chu PY, Tzeng YT, Tsui KH, Chu CY, Li CJ. Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer. Aging (Albany NY). 2022 Mar 5;14(5):2252-2267.

11. Hou YL, Li CJ, Lin LT, Chen SN, Wen ZH, Tsui KH. DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders. Taiwan J Obstet Gynecol. 2022 Mar;61(2):223-229.

12. Li CJ, Lin LT, Tsai HW, Wen ZH, Tsui KH. Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. Aging Cell. 2022 Feb;21(2):e13546.

13. Wen CY, Tsui KH, Chang CH, Chiu YH, Lin SA, Chu CY, Li CJ. Integrative Multiomics Evaluation of IIDH1 Metabolic Enzyme as a Candidate Oncogene That is Correlated with Poor Prognosis and Immune Infiltration in Prostate Adenocarcinoma. J Oncol. 2022 Jan 29;2022:9854788.

14. Hsu LC, Tu TY, Chen HY, Chang R, Yip HT, Chou MC, Wei JC, Tsui KH, Sheu JJ. Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study. J Pers Med. 2022 Jan 27;12(2):172.

15. Chang CY, Chiang AJ, Lai MT, Yan MJ, Tseng CC, Lo LC, Wan L, Li CJ, Tsui KH, Chen CM, Hwang T, Tsai FJ, Sheu JJ. A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study. Biomedicines. 2022 Jan 14;10(1):174.

16. Tsai HW, Liao PF, Li CJ, Lin LT, Wen ZH, Tsui KH. High serum anti-Müllerian hormone concentrations have a negative impact on fertilization and embryo development rates. Reprod Biomed Online. 2022 Jan;44(1):171-176.

17. Chen YP, Shih PC, Feng CW, Wu CC, Tsui KH, Lin YH, Kuo HM, Wen ZH. Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species. Antioxidants (Basel). 2021 Nov 25;10(12):1883.

18. Wang PH, Lee WL, Yang ST, Tsui KH, Chang CC, Lee FK. The impact of COVID-19 in pregnancy: Part II. Vaccination to pregnant women. J Chin Med Assoc. 2021 Oct 1;84(10):903-910.

19. Wen ZH, Huang SY, Kuo HM, Chen CT, Chen NF, Chen WF, Tsui KH, Liu HT, Sung CS. Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury. Biomedicines. 2021 Sep 10;9(9):1187.

20. Wang PH, Lee WL, Yang ST, Tsui KH, Chang CC, Lee FK. The impact of COVID-19 in pregnancy: Part I. Clinical presentations and untoward outcomes of pregnant women with COVID-19. J Chin Med Assoc. 2021 Aug 5.

21. Li CJ, Lin LT, Tsui KH*. Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age. Nutrients. 2021 Jul 17;13(7):2449.(corresponding author)

22. Cheng SY, Chen NF, Wen ZH, Yao ZK, Tsui KH, Kuo HM, Chen WF. Glutathione S-ransferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. Int J Mol Sci. 2021 Jun 30;22(13):7080. 

23. Li CJ, Lin LT, Tsai HW, Chern CU, Wen ZH, Wang PH, Tsui KH*. The Molecular Regulation in the Pathophysiology in Ovarian Aging. Li CJ, Lin LT, Tsai HW, Chern CU, Wen ZH, Wang PH, Tsui KH*. Aging Dis. 2021 Jun 1;12(3):934-949.(corresponding author)

24. Li CJ, Lin LT, Chu PY, Chiang AJ, Tsai HW, Chiu YH, Huang MS, Wen ZH, Tsui KH*. Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer. J Pers Med. 2021 Apr 19;11(4):316.(corresponding author)

25. Lin LT, Li CJ, Tsui KH*. Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women. Sci Rep. 2021 Mar 18;11(1):6336.(corresponding author)

26. Lin LT, Tsui KH*. The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study. J Clin Med. 2021 Mar 15;10(6):1211.(corresponding author)

27. Chen YC, Li JY, Li CJ, Tsui KH, Wang PH, Wen ZH, Lin LT. Luteal Phase Ovarian Stimulation versus Follicular Phase Ovarian Stimulation results in different Human Cumulus cell genes expression: A pilot study. Int J Med Sci. 2021 Feb 4;18(7):1600-1608.

28. Pan LF, Wang PH, Lin LT, Hsu S, Tsui KH*. Factors that infertile couples from mainland China may take into consideration for cross-border reproductive care - A cross-sectional questionnaire study. Taiwan J Obstet Gynecol. 2021 Jan;60(1):24-30.(corresponding author)

29. Chiang AJ, Li CJ, Tsui KH, Chang C, Chang YI, Chen LW, Chang TH, SheuJJ.UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.Biomolecules. 2020 Dec 30;11(1):37.

30. Cheng M, Chang WH, Yang ST, Huang HY, Tsui KH, Chang CP, Lee WL, Wang PH. Efficacy of Applying Hyaluronic Acid Gels in the Primary Prevention of Intrauterine Adhesion after Hysteroscopic Myomectomy: A Meta-Analysis of Randomized Controlled Trials. Life (Basel). 2020 Nov 15;10(11):E285.

31. Seow KM, Chang YW, Chen KH, Juan CC, Huang CY, Lin LT, Tsui KH, Chen YJ, Lee WL, Wang PH. Molecular Mechanisms of Laparoscopic Ovarian Drilling and Its Therapeutic Effects in Polycystic Ovary Syndrome. Int J Mol Sci. 2020 Oct 31;21(21):8147.

32. Hsu LC, Tsui KH, Wei JC, Yip HT, Hung YM, Chang R. Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study. Int J Environ Res Public Health. 2020 Sep 7;17(18):E6505.

33. Tsui KH, Lee WL, Wang PH. Advanced technology offers a safer and better laparoscopic surgery. J Chin Med Assoc. 2020 Aug;83(8):697-698. (first author)

34. Chern CU, Li JY, Tsui KH, Wang PH, Wen ZH, Lin LT. Dual-trigger improves the outcomes of in vitro fertilization cycles in older patients with diminished ovarian reserve: A retrospective cohort study. PLoS One. 2020 Jul 6;15(7):e0235707.

35. Lin PH, Lin LT, Li CJ, Kao PG, Tsai HW, Chen SN, Wen ZH, Wang PH, Tsui KH*. Combining Bioinformatics and Experiments to Identify CREB1 as a Key Regulator in Senescent Granulosa Cells. Diagnostics (Basel). 2020 May 11;10(5):295.(corresponding author)

36. Tsai HW, Wang PH, Hsu PT, Chen SN, Lin LT, Li CJ, Tsui KH*. Laser irradiation pretreatment improves endometrial preparation of frozen-thawed embryo transfer in recurrent implantation failure patients. Gynecol Endocrinol. 2020 Aug;36(8):734-

738. (corresponding author)

37. Li JY, Li CJ, Lin LT, Tsui KH*.Multi-Omics Analysis Identifying Key Biomarkers in Ovarian Cancer.Cancer Control. 2020 Jan-Dec;27(1):1073274820976671.(corresponding author)

38. Chen SN, Tsui KH, Wang PH, Chern CU, Wen ZH, Lin LT. Dehydroepiandrosterone Supplementation Improves the Outcomes of in vitro Fertilization Cycles in Older Patients With Diminished Ovarian Reserve. Front Endocrinol (Lausanne). 2019 Nov 15;10:800.

39. Tsui KH, Wu MY, Lin LT, Wen ZH, Li YH, Chu PY, Li CJ. Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms. Theranostics. 2019 Sep 17;9(22):6631-6645. (first author)

40. Pan LF, Wang PH, Lin LT, Hsu S, Tsui KH*. Factors that influence infertile couples' selection of reproductive medicine centers---A cross-sectional questionnaire study. Taiwan J Obstet Gynecol. 2019 Sep;58(5):633-639. (corresponding author)

41. Cheng MH, Huang HL, Lin YY, Tsui KH, Chen PC, Cheng SY, Chong IW, Sung PJ, Tai MH, Wen ZH, Chen NF, Kuo HM. BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells. Oxid Med Cell Longev. 2019 May 7;2019:6342104.

42. Li JY, Wang PH, Vitale SG, Chen SN, Marranzano M, Cianci A, Lin LT, Tsui KH*. Pregnancy-induced hypertension is an independent risk factor for meconium aspiration syndrome: A retrospective population based cohort study. Taiwan J Obstet Gynecol. 2019 May;58(3):396-400. (corresponding author)

43. Chen SN, Chang R, Lin LT, Chern CU, Tsai HW, Wen ZH, Li YH, Li CJ, Tsui KH*.MicroRNA in Ovarian Cancer: Biology, Pathogenesis, and Therapeutic Opportunities. Int J Environ Res Public Health. 2019 Apr 29;16(9). pii: E1510. (corresponding author)

44. Chen SN, Wang PH, Hsieh MF, Tsai HW, Lin LT, Tsui KH*. Maternal pregnancy-inducedhypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study. Taiwan J Obstet Gynecol. 2019 Mar;58(2):261-265.(corresponding author)