标题:高刚度感知下Notch1 O-GlcNAc糖基化修饰促进肿瘤力学特性重塑介导脊索瘤复发的研究
刘蕾
单位:重庆医科大学 科室:分子肿瘤与表观遗传学实验室
简历
刘蕾,重庆医科大学,附属第一医院,助理研究员
教育经历:
(1) 2011.9–2016.6,中山大学,分子医学,博士,导师:黎孟枫
(2) 2006.9–2011.6,中山大学,临床医学,学士。
科研与学术工作经历
(1) 2019.9至今,重庆医科大学,附属第一医院,助理研究员
(2) 2016.7-2019.7,中山大学,中山医学院,特聘副研究员
主持或参加的各类科研项目及人才计划项目:
(1)国家自然科学基金青年科学基金项目,81902965,2020.01-2022.12, 在研,主持;
(2)广东省自然科学基金项目面上项目,2018A0303130260,2018.5-2021.4,在研,主持;
(3)广州市科技计划项目科学研究计划一般项目专题,201804010057,2018.4-2021.3,在研,主持;
(4)中央高校基本科研业务费中山大学青年教师培育项目,No. 17ykpy06, 2017.1-2019.12,已结题,主持;
(5)广州市科技计划项目民生科技攻关计划生物医药与健康专题,201803010039,2018.4-2021.3,在研,参与;
(6)此外参与其他国家自然科学基金项目6项,其中重大项目1项(420万元),面上项目5项。
代表性研究成果和学术奖励情况
(1)Liu, Lei#; Wang, Tingting; Yang, Xiaoming; Xu, Caixia; Liao, Zhiheng; Wang, Xudong; Su, Deying; Li, Yongyong; Zhou, Hang; Qiu, Xianjian; Chen, Yuyu; Huang, Dongsheng; Lian, Chengjie*; Su, Peiqiang*. MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression. Journal of Pineal Research, 2019 Sep;67(2):e12588.
(2)Liu, Lei#; Yang, Yi #*; Liu, Shihua; Tao, Tianyu; Cai, Junchao; Wu, Jueheng; Guan, Hongyu; Zhu, Xun; He, Zhenjian; Li, Jun; Song, Erwei; Zeng, Musheng; Li, Mengfeng*. EGF-induced nuclear localization of SHCBP1 activatesβ-catenin signaling and promotes cancer progression. Oncogene, 2018 Sep 3.
(3)Liu, Lei #; Wu, Shanshan # ; Yang, Yi; Cai, Junchao; Zhu, Xun; Wu, Jueheng; Li, Mengfeng; Guan, Hongyu*. SOSTDC1 is down-regulated in non-small cell lung cancer and contributes to cancer cell proliferation. Cell Biosci, 2016, 6: 24~24.
(4)Yang, Yi #; Liu, Lei; Zhang, Ying; Guan, Hongyu; Wu, Jueheng; Zhu, Xun; Yuan, Jie; Li, Mengfeng*. MiR-503 targets PI3K p85 and IKK-β and suppresses progression of non-small cell lung cancer. Int J Cancer, 2014.10.1, 135(7): 1531~1542.
(5)Yang, Yi #; Liu, Lei #; Cai, Junchao; Wu, Jueheng; Guan, Hongyu; Zhu,Xun; Yuan, Jie; Li, Mengfeng*. DEPDC1B enhances migration and invasion of non-small cell lung cancer cells via activating Wnt/β-catenin signaling. Biochem Biophys Res Commun, 2014.7.18, 450(1): 899~905.
(6)Yang, Yi #; Liu, Lei; Cai, Junchao; Wu, Jueheng; Guan, Hongyu; Zhu, Xun; Yuan, Jie; Chen, Shengping; Li, Mengfeng*. Targeting Smad2 and Smad3 by miR-136 suppresses metastasis-associated traits of lung adenocarcinoma cells. Oncol Res, 2013, 21(6): 345~352.
(7)Li, Mengfeng #*; Li, Jun; Liu, Lei; Li, Wei; Yang, Yi; Yuan, Jie. MicroRNA in Human Glioma. Cancers, 2013.10.23, 5(4): 1306~1331.